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The significant increase in OsDJ-1 gene expression in response to MG suggests that MG may acts as a direct substrate for OsDJ-1 proteins and thus induce the expression of gene through substrate inducible mechanism 34

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Environmental exposures, DNA methylation and SLE Many lifestyle factors, including diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants and psychological stress, have been shown to modify DNA methylation patterns.101104 For example, environmental chemicals directly act on the function of DNMT and TET enzyme families